Conjoined NO-sensitive guanylyl cyclases
نویسندگان
چکیده
منابع مشابه
Conjoined NO-sensitive guanylyl cyclases
Background NO-sensitive guanylyl cyclases (NO-GC’s) that catalyze the reaction of GTP to the second messenger molecule cGMP are heterodimeric enzymes consisting of an a and a b1 subunit. The two prevalent isoforms in humans (a1/b1, a2/b1) are time-tested targets for drugs that release nitric oxide (NO) and new compounds that either sensitize the enzyme for activation by NO or activate the enzym...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2011
ISSN: 1471-2210
DOI: 10.1186/1471-2210-11-s1-p6